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Table 1.
Literature overview.
| Title | Authors | Number of cases | Treatment modalities | Mean follow-up (years) | Oncologic outcome |
|---|---|---|---|---|---|
| Amputation for extremity soft tissue sarcoma does not increase overall survival: A retrospective cohort study | Alamanda et al. | 278 | LSS vs. amputation | 3.1 | No difference between mortality, distant metastases, and local recurrence |
| Long-term outcome after local recurrence of soft tissue sarcoma: a retrospective analysis of factors predictive of survival in 135 patients with locally recurrent soft tissue sarcoma | Daigeler et al. | 135 | LSS with or without adjuvant chemo and/or radiation | 12.3 | Significant prognostic indicators for post-resection survival were histologic grade, tumor site, time to initial recurrence, the number of recurrences, and the surgical margin status attained at the last resection. |
| Neoadjuvant Chemotherapy and Radiotherapy for Large Extremity Soft Tissue Sarcomas | DeLaney et al. | 48 | Adjuvant chemo and radiation vs. no adjuvant treatment | 4 | Gain in disease-free and overall survival compared with a historical control group |
| Recurrent aggressive chondrosarcoma of the middle phalanx of the index finger: excision and reconstruction with an osteocartilaginous allograft | Exner et al. | 1 | LSS | 12 | Digit-sparing techniques may be considered rather than ablative procedures |
| A randomized phase II study on neo-adjuvant chemotherapy for ‘high-risk’ adult soft tissue sarcoma | Gortzak et al. | 134 | Amputation or LSS with or without chemotherapy | 7.3 | Neo-adjuvant chemotherapy does not negatively affect the ability to perform surgery |
| Neo-adjuvant chemotherapy alone or with regional hyperthermia for localized high-risk soft tissue sarcoma: a randomized phase III multicenter study | Issels et al. | 341 | Neoadjuvant chemotherapy with or without regional hypothermia | 2.8 | Regional hyperthermia increases the benefit of chemotherapy |
| Squamous Cell Carcinoma of the Skin of the Trunk and Limbs: The Incidence of Metastases and Their Outcome | Joseph et al. | 695 | LSS or amputation | 4 | Risk factors associated with the development of metastatic disease were: delayed presentation: large neglected lesions: misdiagnosis; and multiple treatments to the primary lesion |
| Limb Salvage Surgery and Adjuvant Radiotherapy for Soft Tissue Sarcomas of the Forearm and Hand | Bray et al. | 25 | LSS or amputation | 3.1 | Limb salvage surgery, with adjuvant radiotherapy when necessary, is an effective alternative to amputation in the majority of patients with sarcoma of the forearm and hand. |
| Localized Operable Soft Tissue Sarcoma of the Upper Extremity | Collin et al. | 108 | LSS or amputation | 8.2 | Predictors of local failure: presentation with local recurrence, surgery by LSS, inadequate margins, angiosarcoma, and invasion of vital structures. |
| Primary reconstruction with digital ray transposition after resection of malignant tumor | Muramatsu et al. | 4 | Digital ray transposition after tumor resection | 6.9 | Primary reconstruction with digital ray trans position produces acceptable functional outcomes after resection of malignant tumor. |
| Preoperative versus postoperative radiotherapy in soft tissue sarcoma of the limbs: a randomized trial | O’Sullivan et al. | 190 | Preoperative radiation vs. postoperative radiation | 3.3 | Choice of regimen for patients with soft tissue sarcoma should take into account the timing of surgery and radiotherapy, and the size and anatomical site of the tumor |
| Outcomes after flap reconstruction for extremity soft tissue sarcoma: A case-control study using propensity score analysis | Kang et al. | 148 | Flap reconstruction vs. primary closure | 5.4 | Flap reconstruction had increased morbidity associated with flap reconstruction, but better local control, when compared to patients with primary closure |
| Chondrosarcoma of Small Bones of the Hand | Patil et al. | 23 | Curettage, excision, ray resection/amputation | 8.5 | Results show a high rate of recurrence following curettage, therefore it cannot be recommended for most patients |
| Single Ray Amputation for Tumors of the Hand | Puhaindran et al. | 25 | Ray amputation with or without radiotherapy | 3 | Single ray amputation for hand tumors has low recurrence rates and high functional scores |
| Treatment of Soft Tissue Sarcomas of the Extremity | Rosenberg et al. | 43 | LSS vs. amputation | 3 | LSS, radiation therapy, and adjuvant chemotherapy are capable of successfully treating the majority of adult patients with soft tissue sarcomas of the extremity |
| Standardization of rehabilitation after limb salvage surgery for sarcomas improves patients’ outcome | Shehadeh et al. | 59 | LSS | 2 | Use of standardized rehabilitation protocol resulted in improved patient functional outcome |
| Functional and oncological outcomes after limb salvage surgery for primary sarcomas of the upper limb | Wright et al. | 72 | LSS with or without adjuvant chemotherapy and/or radiotherapy | 2.8 | Limb salvage surgery is applicable to a wide range of tumor types and grades, to all patient age groups, and anatomical sites with good functional results |
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