|Title||Authors||Number of cases||Treatment modalities||Mean follow-up (years)||Oncologic outcome|
|Amputation for extremity soft tissue sarcoma does not increase overall survival: A retrospective cohort study||Alamanda et al.||278||LSS vs. amputation||3.1||No difference between mortality, distant metastases, and local recurrence|
|Long-term outcome after local recurrence of soft tissue sarcoma: a retrospective analysis of factors predictive of survival in 135 patients with locally recurrent soft tissue sarcoma||Daigeler et al.||135||LSS with or without adjuvant chemo and/or radiation||12.3||Significant prognostic indicators for post-resection survival were histologic grade, tumor site, time to initial recurrence, the number of recurrences, and the surgical margin status attained at the last resection.|
|Neoadjuvant Chemotherapy and Radiotherapy for Large Extremity Soft Tissue Sarcomas||DeLaney et al.||48||Adjuvant chemo and radiation vs. no adjuvant treatment||4||Gain in disease-free and overall survival compared with a historical control group|
|Recurrent aggressive chondrosarcoma of the middle phalanx of the index finger: excision and reconstruction with an osteocartilaginous allograft||Exner et al.||1||LSS||12||Digit-sparing techniques may be considered rather than ablative procedures|
|A randomized phase II study on neo-adjuvant chemotherapy for ‘high-risk’ adult soft tissue sarcoma||Gortzak et al.||134||Amputation or LSS with or without chemotherapy||7.3||Neo-adjuvant chemotherapy does not negatively affect the ability to perform surgery|
|Neo-adjuvant chemotherapy alone or with regional hyperthermia for localized high-risk soft tissue sarcoma: a randomized phase III multicenter study||Issels et al.||341||Neoadjuvant chemotherapy with or without regional hypothermia||2.8||Regional hyperthermia increases the benefit of chemotherapy|
|Squamous Cell Carcinoma of the Skin of the Trunk and Limbs: The Incidence of Metastases and Their Outcome||Joseph et al.||695||LSS or amputation||4||Risk factors associated with the development of metastatic disease were: delayed presentation: large neglected lesions: misdiagnosis; and multiple treatments to the primary lesion|
|Limb Salvage Surgery and Adjuvant Radiotherapy for Soft Tissue Sarcomas of the Forearm and Hand||Bray et al.||25||LSS or amputation||3.1||Limb salvage surgery, with adjuvant radiotherapy when necessary, is an effective alternative to amputation in the majority of patients with sarcoma of the forearm and hand.|
|Localized Operable Soft Tissue Sarcoma of the Upper Extremity||Collin et al.||108||LSS or amputation||8.2||Predictors of local failure: presentation with local recurrence, surgery by LSS, inadequate margins, angiosarcoma, and invasion of vital structures.|
|Primary reconstruction with digital ray transposition after resection of malignant tumor||Muramatsu et al.||4||Digital ray transposition after tumor resection||6.9||Primary reconstruction with digital ray trans position produces acceptable functional outcomes after resection of malignant tumor.|
|Preoperative versus postoperative radiotherapy in soft tissue sarcoma of the limbs: a randomized trial||O’Sullivan et al.||190||Preoperative radiation vs. postoperative radiation||3.3||Choice of regimen for patients with soft tissue sarcoma should take into account the timing of surgery and radiotherapy, and the size and anatomical site of the tumor|
|Outcomes after flap reconstruction for extremity soft tissue sarcoma: A case-control study using propensity score analysis||Kang et al.||148||Flap reconstruction vs. primary closure||5.4||Flap reconstruction had increased morbidity associated with flap reconstruction, but better local control, when compared to patients with primary closure|
|Chondrosarcoma of Small Bones of the Hand||Patil et al.||23||Curettage, excision, ray resection/amputation||8.5||Results show a high rate of recurrence following curettage, therefore it cannot be recommended for most patients|
|Single Ray Amputation for Tumors of the Hand||Puhaindran et al.||25||Ray amputation with or without radiotherapy||3||Single ray amputation for hand tumors has low recurrence rates and high functional scores|
|Treatment of Soft Tissue Sarcomas of the Extremity||Rosenberg et al.||43||LSS vs. amputation||3||LSS, radiation therapy, and adjuvant chemotherapy are capable of successfully treating the majority of adult patients with soft tissue sarcomas of the extremity|
|Standardization of rehabilitation after limb salvage surgery for sarcomas improves patients’ outcome||Shehadeh et al.||59||LSS||2||Use of standardized rehabilitation protocol resulted in improved patient functional outcome|
|Functional and oncological outcomes after limb salvage surgery for primary sarcomas of the upper limb||Wright et al.||72||LSS with or without adjuvant chemotherapy and/or radiotherapy||2.8||Limb salvage surgery is applicable to a wide range of tumor types and grades, to all patient age groups, and anatomical sites with good functional results|
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