Table 1.

Literature overview.

Title Authors Number of cases Treatment modalities Mean follow-up (years) Oncologic outcome
Amputation for extremity soft tissue sarcoma does not increase overall survival: A retrospective cohort study
 Alamanda et al. 278 LSS vs. amputation 3.1 No difference between mortality, distant metastases, and local recurrence
Long-term outcome after local recurrence of soft tissue sarcoma: a retrospective analysis of factors predictive of survival in 135 patients with locally recurrent soft tissue sarcoma Daigeler et al. 135 LSS with or without adjuvant chemo and/or radiation 12.3 Significant prognostic indicators for post-resection survival were histologic grade, tumor site, time to initial recurrence, the number of recurrences, and the surgical margin status attained at the last resection.
Neoadjuvant Chemotherapy and Radiotherapy for Large Extremity Soft Tissue Sarcomas DeLaney et al. 48 Adjuvant chemo and radiation vs. no adjuvant treatment 4 Gain in disease-free and overall survival compared with a historical control group
Recurrent aggressive chondrosarcoma of the middle phalanx of the index finger: excision and reconstruction with an osteocartilaginous allograft Exner et al. 1 LSS 12 Digit-sparing techniques may be considered rather than ablative procedures
A randomized phase II study on neo-adjuvant chemotherapy for ‘high-risk’ adult soft tissue sarcoma Gortzak et al. 134 Amputation or LSS with or without chemotherapy 7.3 Neo-adjuvant chemotherapy does not negatively affect the ability to perform surgery
Neo-adjuvant chemotherapy alone or with regional hyperthermia for localized high-risk soft tissue sarcoma: a randomized phase III multicenter study Issels et al. 341 Neoadjuvant chemotherapy with or without regional hypothermia 2.8 Regional hyperthermia increases the benefit of chemotherapy
Squamous Cell Carcinoma of the Skin of the Trunk and Limbs: The Incidence of Metastases and Their Outcome Joseph et al. 695 LSS or amputation 4 Risk factors associated with the development of metastatic disease were: delayed presentation: large neglected lesions: misdiagnosis; and multiple treatments to the primary lesion
Limb Salvage Surgery and Adjuvant Radiotherapy for Soft Tissue Sarcomas of the Forearm and Hand Bray et al. 25 LSS or amputation 3.1 Limb salvage surgery, with adjuvant radiotherapy when necessary, is an effective alternative to amputation in the majority of patients with sarcoma of the forearm and hand.
Localized Operable Soft Tissue Sarcoma of the Upper Extremity Collin et al. 108 LSS or amputation 8.2 Predictors of local failure: presentation with local recurrence, surgery by LSS, inadequate margins, angiosarcoma, and invasion of vital structures.
Primary reconstruction with digital ray transposition after resection of malignant tumor Muramatsu et al. 4 Digital ray transposition after tumor resection 6.9 Primary reconstruction with digital ray trans position produces acceptable functional outcomes after resection of malignant tumor.
Preoperative versus postoperative radiotherapy in soft tissue sarcoma of the limbs: a randomized trial O’Sullivan et al. 190 Preoperative radiation vs. postoperative radiation 3.3 Choice of regimen for patients with soft tissue sarcoma should take into account the timing of surgery and radiotherapy, and the size and anatomical site of the tumor
Outcomes after flap reconstruction for extremity soft tissue sarcoma: A case-control study using propensity score analysis Kang et al. 148 Flap reconstruction vs. primary closure 5.4 Flap reconstruction had increased morbidity associated with flap reconstruction, but better local control, when compared to patients with primary closure
Chondrosarcoma of Small Bones of the Hand Patil et al. 23 Curettage, excision, ray resection/amputation 8.5 Results show a high rate of recurrence following curettage, therefore it cannot be recommended for most patients
Single Ray Amputation for Tumors of the Hand Puhaindran et al. 25 Ray amputation with or without radiotherapy 3 Single ray amputation for hand tumors has low recurrence rates and high functional scores
Treatment of Soft Tissue Sarcomas of the Extremity Rosenberg et al. 43 LSS vs. amputation 3 LSS, radiation therapy, and adjuvant chemotherapy are capable of successfully treating the majority of adult patients with soft tissue sarcomas of the extremity
Standardization of rehabilitation after limb salvage surgery for sarcomas improves patients’ outcome Shehadeh et al. 59 LSS 2 Use of standardized rehabilitation protocol resulted in improved patient functional outcome
Functional and oncological outcomes after limb salvage surgery for primary sarcomas of the upper limb Wright et al. 72 LSS with or without adjuvant chemotherapy and/or radiotherapy 2.8 Limb salvage surgery is applicable to a wide range of tumor types and grades, to all patient age groups, and anatomical sites with good functional results

LSS = limb salvage surgery.

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