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Table 3.
Comparison of the NOVOCART® Inject and Chondrosphere.
| NOVOCART® Inject | Chondrosphere® |
|---|---|
| Cultivation within 3–4 weeks with pooled serum, BMP-2 and insulin | Cultivation within 6–7 weeks in 200 mL autologous serum |
| Injectable through a deformable needle | Injectable through a deformable applicator |
| Polymerized within 2 min after application through polyethylene glycol crosslinking | Bonding of chondrospheres after approximately 20 min |
| Characterized autologous chondrocytes and in situ polymerizing albumin-hyaluronic acid gel, phenotypic stability, positive biologic effects (Inhibition of alkaline phosphatase, vascularization, neurotrophic factors) | Complete autologous cell product, phenotypic stability, produces cartilage-specific matrix by induction of three-dimensional cell-cell contacts, biocompatibility |
| RCT at the knee running, studies with evidence level III at the knee | RCT at the knee running, multiple evidence level II and III studies at the hip, knee and ankle |
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