Open Access
Table A.8.
Subgroup analysis by tobacco consumption.
| Follow up visit | Mean value and comparison within time period |
Comparison by time within subgroups (Bonferroni adjusted p-value) |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Smokers |
Non smokers |
|
Smokers |
Non smokers |
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| Unadjusted mean ± SD (n) | Unadjusted mean ± SD (n) | p-value | Preop | 6 Month | 1 Year | 2 Year | 3 Year | Preop | 6 Month | 1 Year | 2 Year | 3 Year | |
| UCLA | |||||||||||||
| Preop | 3.9 ± 1.4 (26) | 3.8 ± 1.6 (196) | 0.7261 | – | – | – | – | – | – | – | – | – | – |
| 6 Month | 5.0 ± 1.2 (23) | 5.6 ± 1.4 (172) | 0.0699 | 0.0042* | – | – | – | – | <.0001* | – | – | – | – |
| 1 Year | 6.2 ± 1.8 (17) | 5.9 ± 1.6 (161) | 0.4296 | 0.0018* | 1.0000 | – | – | – | <.0001* | 0.0653 | – | – | – |
| 2 Year | 6.2 ± 1.7 (16) | 6.1 ± 1.6 (129) | 0.8755 | 0.0110* | 0.8057 | 1.0000 | – | – | <.0001* | 0.0004* | 1.0000 | – | – |
| 3 Year | 6.0 ± 1.5 (16) | 6.2 ± 1.6 (127) | 0.5333 | 0.0037* | 1.0000 | 1.0000 | 1.0000 | – | <.0001* | 0.0002* | 1.0000 | 1.0000 | – |
| 5 Year | 6.4 ± 0.9 (5) | 6.5 ± 1.5 (71) | 0.8782 | 0.0042* | 0.2710 | 1.0000 | 1.0000 | 1.0000 | <.0001* | 0.0258* | 1.0000 | 1.0000 | 1.0000 |
| EQ5D | |||||||||||||
| Preop | 0.4 ± 0.3 (26) | 0.5 ± 0.3 (196) | 0.2153 | – | – | – | – | – | – | – | – | – | – |
| 6 Month | 0.9 ± 0.1 (23) | 0.9 ± 0.2 (170) | 0.4689 | <.0001* | – | – | – | – | <.0001* | – | – | – | – |
| 1 Year | 1.0 ± 0.1 (17) | 0.9 ± 0.2 (159) | 0.1436 | 0.0002* | 0.2344 | – | – | – | <.0001* | 0.0852 | – | – | – |
| 2 Year | 0.9 ± 0.3 (16) | 0.9 ± 0.1 (128) | 0.7519 | 0.0023* | 1.0000 | 1.0000 | – | – | <.0001* | 0.1393 | 1.0000 | – | – |
| 3 Year | 0.9 ± 0.2 (16) | 0.9 ± 0.2 (127) | 0.314 | 0.0005* | 1.0000 | 1.0000 | 1.0000 | – | <.0001* | 1.0000 | 1.0000 | 1.0000 | – |
| 5 Year | 1.0 ± 0.0 (5) | 0.9 ± 0.1 (68) | 0.2101 | 0.9375 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | <.0001* | 0.0001* | 1.0000 | 0.7060 | 1.0000 |
| HHS | |||||||||||||
| Preop | 49.2 ± 11.8 (26) | 49.5 ± 13.0 (196) | 0.8863 | – | – | – | – | – | – | – | – | – | – |
| 6 Month | 97.4 ± 4.3 (23) | 93.3 ± 9.2 (171) | 0.0289* | <.0001* | – | – | – | – | <.0001* | – | – | – | – |
| 1 Year | 98.5 ± 3.1 (17) | 96.1 ± 6.9 (160) | 0.1225 | 0.0002* | 1.0000 | – | – | – | <.0001* | <.0001* | – | – | – |
| 2 Year | 98.3 ± 3.6 (16) | 96.1 ± 7.4 (128) | 0.207 | 0.0005* | 1.0000 | 1.0000 | – | – | <.0001* | <.0001* | 1.0000 | – | – |
| 3 Year | 98.2 ± 2.6 (16) | 96.8 ± 7.5 (126) | 0.5922 | 0.0005* | 1.0000 | 1.0000 | 1.0000 | – | <.0001* | <.0001* | 1.0000 | 1.0000 | – |
| 5 Year | 99.0 ± 1.4 (5) | 97.2 ± 4.8 (68) | 0.6121 | 0.9375 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | <.0001* | <.0001* | 1.0000 | 0.3798 | 1.0000 |
| Oxford | |||||||||||||
| Preop | 20.7 ± 6.2 (26) | 22.2 ± 7.8 (196) | 0.2549 | – | – | – | – | – | – | – | – | – | – |
| 6 Month | 44.7 ± 4.1 (23) | 43.2 ± 5.6 (172) | 0.2523 | <.0001* | – | – | – | – | <.0001* | – | – | – | – |
| 1 Year | 47.0 ± 1.7 (17) | 44.6 ± 5.0 (161) | 0.0420* | 0.0002* | 0.0073* | – | – | – | <.0001* | 0.0021* | – | – | – |
| 2 Year | 45.9 ± 3.7 (16) | 45.3 ± 4.3 (129) | 0.4761 | 0.0005* | 1.0000 | 1.0000 | – | – | <.0001* | <.0001* | 0.0698 | – | – |
| 3 Year | 46.9 ± 1.6 (16) | 45.7 ± 4.2 (126) | 0.5381 | 0.0005* | 0.6152 | 1.0000 | 1.0000 | – | <.0001* | <.0001* | 0.0293* | 1.0000 | – |
| 5 Year | 47.2 ± 1.3 (5) | 46.4 ± 2.7 (71) | 0.5873 | 0.9375 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | <.0001* | <.0001* | 0.7167 | 1.0000 | 1.0000 |
| Aluminum (μg/L) | |||||||||||||
| Preop | 12.7 ± 1.8 (3) | 12.0 ± 1.9 (28) | 0.3002 | – | – | – | – | – | – | – | – | – | – |
| 6 Month | 11.01.8 (5) | 12.5 ± 1.8 (20) | 0.6434 | 1.0000 | – | – | – | – | 1.0000 | – | – | – | – |
| 1 Year | 14.1 ± 3.8 (5) | 14.2 ± 4.0 (19) | 0.2143 | 1.0000 | 0.75 | – | – | – | 0.1855 | 1.0000 | – | – | – |
| 2 Year | 12.3 ± 3.8 (4) | 14.1 ± 4.0 (17) | 0.5015 | 1.0000 | 1.0000 | 1.0000 | – | – | 1.0000 | 1.0000 | 1.0000 | – | – |
| 5 Year | (0) | 14.1 ± 2.5 (7) | – | – | – | – | – | – | 1.0000 | 1.0000 | 1.0000 | – | 1.0000 |
| Titanium (μg/L) | |||||||||||||
| Preop | 1.1 ± 0 (1) | 2.3 ± 0.6 (8) | 0.1213 | – | – | – | – | – | – | – | – | – | – |
| 6 Month | 1.9 ± 1.0 (10) | 2.5 ± 1.9 (33) | 0.3071 | 1.0000 | – | – | – | – | 1.0000 | – | – | – | – |
| 1 Year | 4.5 ± 2.3 (5) | 2.2 ± 1.5 (30) | 0.0376* | 1.0000 | 0. 6250 | – | – | – | 0.6250 | 1.0000 | – | – | – |
| 2 Year | 3.3 ± 0.6 (5) | 2.8 ± 2.7 (22) | 0.0243* | 1.0000 | 1.0000 | 1.0000 | – | – | 1.0000 | 1.0000 | 1.0000 | – | – |
| 5 Year | (0) | 1.3 ± 0.3 (5) | – | – | – | – | – | – | 1.0000 | 1.0000 | 1.0000 | – | 1.0000 |
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