Open Access
Table A.9.
Subgroup analysis by alcohol consumption.
| Follow up visit | Mean value and comparison within time period |
Comparison by time within subgroups (Bonferroni adjusted p-value) |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alcohol consumers |
Non alcohol consumers |
|
Alcohol consumers |
Non alcohol consumers |
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| Unadjusted mean ± SD (n) | Unadjusted mean ± SD (n) | p-value | Preop | 6 Month | 1 Year | 2 Year | 3 Year | Preop | 6 Month | 1 Year | 2 Year | 3 Year | |
| UCLA | |||||||||||||
| Preop | 4.5 ± 1.7 (73) | 3.5 ± 1.5 (149) | <.0001* | – | – | – | – | – | – | – | – | – | – |
| 6 Month | 5.6 ± 1.4 (65) | 5.5 ± 1.4 (130) | 0.4434 | <.0001* | – | – | – | – | <.0001* | – | – | – | – |
| 1 Year | 6.2 ± 1.6 (64) | 5.7 ± 1.6 (114) | 0.0064* | <.0001* | 0.0130* | – | – | – | <.0001* | 0.9955 | – | – | – |
| 2 Year | 6.5 ± 1.6 (54) | 5.8 ± 1.6 (91) | 0.0125* | <.0001* | 0.0001* | 1.0000 | – | – | <.0001* | 0.2088 | 1.0000 | – | – |
| 3 Year | 6.4 ± 1.5 (54) | 6.1 ± 1.7 (89) | 0.1955 | <.0001* | 0.0014* | 1.0000 | 1.0000 | – | <.0001* | 0.0187* | 1.0000 | 1.0000 | – |
| 5 Year | 7.0 ± 1.3 (28) | 6.1 ± 1.4 (48) | 0.0195* | <.0001* | 0.0020* | 0.9229 | 1.0000 | 1.0000 | <.0001* | 1.0000 | 1.0000 | 1.0000 | 1.0000 |
| EQ5D | |||||||||||||
| Preop | 0.4 ± 0.3 (73) | 0.5 ± 0.3 (149) | 0.634 | – | – | – | – | – | – | – | – | – | – |
| 6 Month | 0.9 ± 0.2 (64) | 0.9 ± 0.2 (129) | 0.4121 | <.0001* | – | – | – | – | <.0001* | – | – | – | – |
| 1 Year | 0.9 ± 0.1 (63) | 0.9 ± 0.2 (113) | 0.9971 | <.0001* | 0.0396* | – | – | – | <.0001* | 0.6517 | – | – | – |
| 2 Year | 0.9 ± 0.2 (54) | 0.9 ± 0.1 (90) | 0.1211 | <.0001* | 0.1935 | 1.0000 | – | – | <.0001* | 1.0000 | 1.0000 | – | – |
| 3 Year | 0.9 ± 0.2 (54) | 0.9 ± 0.2 (89) | 0.708 | <.0001* | 1.0000 | 1.0000 | 1.0000 | – | <.0001* | 1.0000 | 1.0000 | 1.0000 | – |
| 5 Year | 1.0 ± 0.1 (27) | 0.9 ± 0.1 (46) | 0.2379 | <.0001* | 0.0879 | 1.0000 | 1.0000 | 1.0000 | <.0001* | 0.0031* | 1.0000 | 0.8459 | 1.0000 |
| HHS | |||||||||||||
| Preop | 51.9 ± 13.7 (73) | 48.3 ± 12.3 (149) | 0.0638 | – | – | – | – | – | – | – | – | – | – |
| 6 Month | 92.6 ± 7.9 (64) | 94.4 ± 9.3 (130) | 0.0091* | <.0001* | – | – | – | – | <.0001* | – | – | – | – |
| 1 Year | 96.0 ± 7.4 (64) | 96.5 ± 6.2 (113) | 0.6825 | <.0001* | 0.0005* | – | – | – | <.0001* | <.0001* | – | – | – |
| 2 Year | 97.2 ± 6.2 (54) | 95.8 ± 7.6 (90) | 0.0749 | <.0001* | <.0001* | 1.0000 | – | – | <.0001* | 0.0024* | 1.0000 | – | – |
| 3 Year | 97.2 ± 6.9 (53) | 96.7 ± 7.3 (89) | 0.832 | <.0001* | <.0001* | 1.0000 | 1.0000 | – | <.0001* | 0.0430* | 1.0000 | 1.0000 | – |
| 5 Year | 97.9 ± 3.5 (28) | 97.0 ± 5.3 (45) | 0.7873 | <.0001* | <.0001* | 1.0000 | 1.0000 | 1.0000 | <.0001* | 0.0001* | 1.0000 | 0.6599 | 1.0000 |
| Oxford | |||||||||||||
| Preop | 23.3 ± 7.3 (73) | 21.4 ± 7.7 (149) | 0.1289 | – | – | – | – | – | – | – | – | – | – |
| 6 Month | 42.4 ± 5.1 (64) | 43.8 ± 5.6 (131) | 0.0017* | <.0001* | – | – | – | – | <.0001* | – | – | – | – |
| 1 Year | 44.8 ± 4.9 (64) | 44.8 ± 4.8 (114) | 0.7546 | <.0001* | <.0001* | – | – | – | <.0001* | 0.2514 | – | – | – |
| 2 Year | 45.6 ± 3.3 (54) | 45.2 ± 4.7 (91) | 0.9398 | <.0001* | <.0001* | 0.1791 | – | – | <.0001* | 0.0371* | 1.0000 | – | – |
| 3 Year | 45.9 ± 3.8 (54) | 45.7 ± 4.2 (88) | 0.3502 | <.0001* | <.0001* | 0.1373 | 1.0000 | – | <.0001* | 0.0399* | 0.9436 | 1.0000 | – |
| 5 Year | 46.7 ± 2.4 (28) | 46.3 ± 2.8 (48) | 0.2696 | <.0001* | <.0001* | 0.6017 | 1.0000 | 1.0000 | <.0001* | <.0001* | 1.0000 | 1.0000 | 1.0000 |
| Aluminum (μg/L) | |||||||||||||
| Preop | 11.0 ± 0.6 (2) | 12.2 ± 1.9 (29) | 0.2957 | – | – | – | – | – | – | – | – | – | – |
| 6 Month | (0) | 12.2 ± 1.8 (25) | – | – | – | – | – | – | 1.0000 | – | – | – | – |
| 1 Year | (0) | 14.2 ± 3.6 (24) | – | – | – | – | – | – | 0.3418 | 1.0000 | – | – | – |
| 2 Year | 12.7 ± 1.4 (2) | 13.9 ± 3.8 (19) | 0.9522 | 1.0000 | – | – | – | – | 1.0000 | 1.0000 | 1.0000 | – | – |
| 5 Year | (0) | 14.1 ± 2.5 (7) | – | – | – | – | – | – | 1.0000 | 1.0000 | 1.0000 | – | 1.0000 |
| Titanium (μg/L) | |||||||||||||
| Preop | (0) | 2.1 ± 0.7 (9) | – | – | – | – | – | – | – | – | – | – | – |
| 6 Month | (0) | 2.4 ± 1.7 (43) | – | – | – | – | – | – | 0.625 | – | – | – | – |
| 1 Year | 6.0 ± 0 (1) | 2.4 ± 1.7 (34) | 0.1646 | – | – | – | – | – | 0.625 | 1.0000 | – | – | – |
| 2 Year | 3.1 ± 0.8 (2) | 2.9 ± 2.5 (25) | 0.3075 | – | – | 1.0000 | – | – | 0.9375 | 1.0000 | 1.0000 | – | – |
| 5 Year | (0) | 1.3 ± 0.3 (5) | – | – | – | – | – | – | 1.0000 | 1.0000 | 1.0000 | – | 1.0000 |
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