Table 1
Demographic and surgical details of patients with periprosthetic joint infections (PJIs) following total knee arthroplasty (TKA) treated with a combination of continuous local antibiotic perfusion (CLAP).
| Case | Age (years) | Sex | Affected side | Comorbidity | Body mass index (kg/m2) | Smoking status (Brinkman index) | Acute/chronic infection | Previous TKA surgery (primary/revision) | Time from TKA (days) | Culture | Time from recent infection diagnosis to surgery (days) | Surgery | CRP negative achievement (days from surgery) | Time to 2nd surgery (days) | Follow-up period (months) | Success /failure |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 86 | F | R | HT | 29.4 | Nonsmoker | Acute | Primary | 29 | Negative | 0 | DAIR, insert exchange | 92 | 39.6 | Success | |
| 2 | 77 | M | L | – | 24.1 | Nonsmoker | Acute | Primary | 204 | MSSA | 11 | DAIR, insert exchange | 64 | 17.5 | Success | |
| 3 | 77 | F | L | AP, HT, DLP, DM, asthma, GERD | 19.7 | Nonsmoker | Acute | Primary | 62 | MSSA, Staphylococcus haemolyticus (MRS) | 1 | DAIR, insert exchange | 71 | 14.2 | Success | |
| 4 | 87 | M | R | RA, HT, ARF, prosthesis cancer | 25.1 | Nonsmoker | Acute | Primary | 623 | Escherichia coli | 1 | DAIR, insert exchange | 126 | 1.49 | Success | |
| 5 | 70 | F | R | DM, HT, DLP | 27.6 | Nonsmoker | Acute | Revision | 21 | Staphylococcus epidermidis | 3 | DAIR, insert exchange | 46 | 11.8 | Success | |
| 6 | 49 | F | L | RA | 21.3 | Nonsmoker | Chronic | Primary | 4113 | Staphylococcus epidermidis | 416 | Implant removal, cement spacers, debridement | 14 | 180 | 21.2 | Success |
| 7 | 61 | F | R | – | 38.7 | Nonsmoker | Chronic | Primary | 1021 | MSSA | 17 | Implant removal, cement spacers, debridement | 32 | 168 | 16.5 | Success |
| 8 | 73 | F | L | DM, HT, DLP | 24.9 | Ex-smoker (200) | Chronic | Primary | 2616 | MAC | 27 | Implant removal, cement spacers, debridement | 27 | 20.3 | Success | |
| 9 | 69 | F | L | RA, hypothyroidism | 17.7 | Nonsmoker | Chronic | Primary | 204 | MSSA, Candida | 91 | Implant removal, cement spacers, debridement | 159 | 112 | 40.5 | Success |
| 10 | 71 | F | R | – | 29.1 | Nonsmoker | Chronic | Primary | 482 | MSSA | 72 | Implant removal, cement spacers, debridement | 168 | 148 | 39.9 | Success |
| 11 | 74 | M | L | HT, DLP | 28.1 | Ex-smoker (1,600) | Chronic | Revision | 1647 | Staphylococcus lugdunensis | 63 | Implant removal, cement spacers, debridement | 29 | 133 | 20.7 | Success |
| 12 | 58 | F | R | Sjogren disease, DM, RA, asthma, HT, DLP | 25.2 | Smoker (760) | Chronic | Revision | 316 | Staphylococcus epidermidis | 193 | Implant removal, cement spacers, debridement | 102 | 105 | 14.2 | Success |
| 13 | 70 | M | L | HT, lung cancer, lymphedema, pulmonary fibrosis | 23.5 | Smoker (760) | Chronic | Primary | 1844 | Staphylococcus lugdunensis | 5 | DAIR, insert exchange | 91 | 16.2 | Failure | |
| 71 | M | L | Chronic | Primary | Staphylococcus lugdunensis | 13 | Implant removal, cement spacers, debridement | 62 | 20.7 | Success | ||||||
| 14 | 51 | M | L | – | 22.5 | Smoker (1,120) | Chronic | Primary | 247 | Staphylococcus hominis | 5 | DAIR, insert exchange | 71 | 19.4 | Failure | |
| 52 | M | L | Chronic | Primary | Bacillus species | 28 | Implant removal, cement spacers, debridement | 56 | 14.0 | Success |
HT, hypertension; AP, angina pectoris; DLP, dyslipidemia; DM, diabetes mellitus; GERD, gastroesophageal reflux disease; ARF, acute renal failure; RA, rheumatoid arthritis; MSSA, methicillin-sensitive Staphylococcus aureus; MRS, methicillin-resistant Staphylococcus; MAC, Mycobacterium avium complex; DAIR, debridement, antibiotics and implant retention; CRP, C-reactive protein.
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