Open Access
Table 1
Association of adjuvant chemotherapy with clinical variables in the patients with localized dedifferentiated chondrosarcoma.
| Adjuvant chemotherapy |
||||
|---|---|---|---|---|
| Variable | No. of patients (n = 98) | No (n = 78) | Yes (n = 20) | P value |
| Age (years), n (%) | 0.019* | |||
| < 40 | 2 (2.0) | 1 (1.3) | 1 (5.0) | |
| 40–65 | 40 (40.8) | 27 (34.6) | 13 (65.0) | |
| > 65 | 56 (57.1) | 50 (64.1) | 6 (30.0) | |
| Sex, n (%) | 0.776 | |||
| Male | 61 (62.2) | 48 (61.5) | 13 (65.0) | |
| Female | 37 (37.8) | 30 (38.5) | 7 (35.0) | |
| Previous surgery, n (%) | 0.339# | |||
| No | 91 (92.9) | 71 (91.0) | 20 (100) | |
| Yes | 7 (7.1) | 7 (9.0) | 0 (0) | |
| Site, n (%) | 0.156 | |||
| Trunk | 41 (41.8) | 29 (37.2) | 12 (60.0) | |
| Upper limb | 20 (20.4) | 18 (23.1) | 2 (10.0) | |
| Lower limb | 37 (37.8) | 31 (39.7) | 6 (30.0) | |
| Tumor size (cm), n (%) | 0.145# | |||
| < 8 | 23 (23.5) | 21 (26.9) | 2 (10.0) | |
| ≥ 8 | 75 (76.5) | 57 (73.1) | 18 (90.0) | |
| Biopsy, n (%) | 0.274 | |||
| None | 10 (10.2) | 9 (11.5) | 1 (5.0) | |
| Needle | 6 (6.1) | 6 (7.7) | 0 | |
| Open | 82 (83.7) | 63 (80.8) | 19 (95.0) | |
| Surgical margin, n (%) | 0.988 | |||
| R0 | 70 (71.4) | 56 (71.8) | 14 (70.0) | |
| R1 or R2 | 14 (14.3) | 11 (14.1) | 3 (15.0) | |
| No surgery | 14 (14.3) | 11 (14.1) | 3 (15.0) | |
| Adjuvant radiotherapy, n (%) | 0.113# | |||
| No | 87 (88.8) | 67 (85.9) | 20 (100) | |
| Yes | 11 (11.2) | 11 (14.1) | 0 | |
| Local recurrence, n (%) | 0.602# | |||
| No | 67 (77.0) | 53 (76.8) | 14 (77.8) | |
| Yes | 20 (23.0) | 16 (23.2) | 4 (22.2) | |
| Distant metastases, n (%) | 0.361 | |||
| No | 45 (45.9) | 34 (43.6) | 11 (55.0) | |
| Yes | 53 (54.1) | 44 (56.4) | 9 (45.0) | |
| Died of disease, n (%) | 0.316 | |||
| No | 49 (50.0) | 37 (47.4) | 12 (60.0) | |
| Yes | 49 (50.0) | 41 (52.6) | 8 (40.0) | |
| Follow-up period after diagnosis (months), median (IQR) | 14.5 (5.8–36.8) | 11 (4–34.6) | 25 (11.5–59.8) | 0.023* |
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