Open Access
Table 3
Cox regression analysis of distant metastasis-free survival in patients with localized dedifferentiated chondrosarcoma.
| Univariate analysis |
|||
|---|---|---|---|
| Variable (n = 98) | No. of patients | Hazard ratio (95% CI) | P value |
| Age (years) | 98 | 1.01 (0.99–1.03) | 0.502 |
| Sex | |||
| Male | 61 | 1 | |
| Female | 37 | 0.99 (0.57–1.71) | 0.977 |
| Previous surgery | |||
| No | 91 | 1 | |
| Yes | 7 | 0.20 (0.03–1.44) | 0.110 |
| Site | |||
| Trunk | 41 | 1 | |
| Upper limb | 20 | 0.71 (0.30–1.70) | 0.441 |
| Lower limb | 37 | 1.81 (1.00–3.29) | 0.049* |
| Tumor size (cm) | 98 | 1.06 (1.00–1.12) | 0.049* |
| Surgical margin | |||
| R0 | 70 | 1 | |
| R1 or R2 | 14 | 0.77 (0.34–1.72) | 0.519 |
| No surgery | 14 | 1.25 (0.53–2.95) | 0.614 |
| Adjuvant radiotherapy | |||
| No | 87 | 1 | |
| Yes | 11 | 1.92 (0.93–3.94) | 0.076 |
| Adjuvant chemotherapy | |||
| No | 78 | 1 | |
| Yes |
20 |
0.54 (0.27–1.12) |
0.097 |
| Multivariate analysis |
|||
| Variable |
No. of patients |
Hazard ratio (95% CI) |
P value |
| Previous surgery | |||
| No | 91 | 1 | |
| Yes | 7 | 0.13 (0.02–0.95) | 0.044* |
| Tumor size (cm) | 98 | 1.09 (1.03–1.15) | 0.003* |
| Adjuvant chemotherapy | |||
| No | 78 | 1 | |
| Yes | 20 | 0.39 (0.18–0.83) | 0.014* |
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