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Table 4
Cox regression analysis of disease-specific survival in patients with localized dedifferentiated chondrosarcoma.
| Univariate analysis |
|||
|---|---|---|---|
| Variable (n = 98) | No. of patients | Hazard ratio (95% CI) | P value |
| Age (years) | 98 | 1.02 (0.99–1.04) | 0.147 |
| Sex | |||
| Male | 61 | 1 | |
| Female | 37 | 0.86 (0.48–1.53) | 0.609 |
| Previous surgery, n (%) | |||
| No | 91 | 1 | |
| Yes | 7 | 0.45 (0.11–1.86) | 0.273 |
| Site | |||
| Trunk | 41 | 1 | |
| Upper limb | 20 | 0.67 (0.30–1.53) | 0.345 |
| Lower limb | 37 | 1.07 (0.58–1.97) | 0.836 |
| Tumor size (cm) | 98 | 1.08 (1.02–1.15) | 0.009* |
| Surgical margin | |||
| R0 | 70 | 1 | |
| R1 or R2 | 14 | 1.33 (0.64–2.78) | 0.450 |
| No surgery | 14 | 2.08 (0.91–4.72) | 0.081 |
| Adjuvant radiotherapy | |||
| No | 87 | 1 | |
| Yes | 11 | 1.38 (0.62–3.07) | 0.435 |
| Adjuvant chemotherapy | |||
| No | 78 | 1 | |
| Yes |
20 |
0.55 (0.26–1.17) |
0.123 |
| Multivariate analysis |
|||
| Variable |
No. of patients |
Hazard ratio (95% CI) |
P value |
| Previous surgery, n (%) | |||
| No | 91 | 1 | |
| Yes | 7 | 0.19 (0.04–0.84) | 0.028* |
| Tumor size (cm) | 98 | 1.13 (1.06–1.19) | <0.001* |
| Surgical margin | |||
| R0 | 70 | 1 | |
| R1 or R2 | 14 | 1.74 (0.81–3.73) | 0.158 |
| No surgery | 14 | 3.87 (1.61–9.28) | 0.002* |
| Adjuvant chemotherapy | |||
| No | 78 | 1 | |
| Yes | 20 | 0.36 (0.16–0.77) | 0.009* |
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