Figure 1
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(A) Post-prandial gut release of GLP-1RA and downstream reduction in bone resorption (CTX) alongside increased osteoblast activity (P1NP). (B) Key nodes of the OPG/RANKL/RANK pathway that GLP-1RA may modulate to limit osteoclastogenesis. (C) System-wide actions of GLP-1RA (weight loss, improved insulin sensitivity) that indirectly enhance the peri-operative bone micro-environment.
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