Volume 7, 2021
|Number of page(s)||5|
|Published online||01 March 2021|
Platelet-rich plasma as an effective biological therapy in early-stage knee osteoarthritis: One year follow up
Senior Resident, Department of Orthopaedics, Trauma Center, BHU, 221005 Varanasi, India
2 Junior Resident, Department of Pediatrics, JNMC, AMU, 202002 Aligarh, India
3 Professor, Department of Orthopaedics, Rohilkhand Medical College, 243006 Bareilly, India
4 Professor, Department of Orthopaedics, S.S. Hospital, BHU, 221005 Varanasi, India
* Corresponding author: firstname.lastname@example.org
Accepted: 2 February 2021
Objective: PRP is produced by centrifugation of whole blood containing highly concentrated platelets, associated growth factors, and other bioactive agents which has been shown to provide some symptomatic relief in early knee osteoarthritis (OA). The principal objective of our study was to evaluate the effectiveness and safety of standardized intra-articular injection of autologous PRP in early osteoarthritis knee. Methods: A total of 98 eligible symptomatic patients received two injections of standardized PRP 3 weeks apart. Clinical outcomes were evaluated using the VAS and Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire before treatment and at 6 weeks, 3 months, 6 months, and 1 year after treatment. Secondary objectives were safety (side effects), and the effect of PRP on the different grades of knee degeneration. Results: There was a statistically significant improvement in mean VAS and WOMAC scores at 6 weeks, 3 months, 6 months, and slight loss of improvement at 1 year follow-up. There was also a correlation between the degree of degeneration and improvement in the mean scores. The decrease in mean pain score is more in grades 1 and 2 (early OA) than in grade 3. The intraarticular injection is safe, with no major complications. Conclusion: PRP is a safe and effective biological regenerative therapy for early OA Knees. It provides a significant clinical improvement in patients with some loss of improvement with time. More studies will be needed to confirm our findings.
Key words: Osteoarthritis / Platelet rich plasma (PRP) / WOMAC pain score
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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