Open Access
Review
Table 1.
Key studies.
| Study (year of publication) | Number of patients | Success rate | Comments |
|---|---|---|---|
| Segawa et al. [4] (1999) | 81 | 85% | Major factor associated with treatment failure was compromised immune status. Bone loss and necrosis of soft tissues also contributed. |
| Marculescu et al. [5] (2006) | 99 | 60% | Sinus tract and duration of symptoms >8 days independent risk factors for failure. |
| Hsieh et al. [30] (2009) | 346 | GN PJI 27% | Debridement alone has a high failure rate and should not be attempted when the duration of symptoms is long. |
| GP PJI 47% | |||
| Deirmengian et al. [23] (2003) | 31 | 35% | Success rate of DAIR depends on involved pathogen. Streptococcal or Staphylococcus epidermidis has better success rate if done within 2–3 days of symptom onset. |
| Triantafyllopoulos et al. [29] (2014) | 78 | 55% | MRSA success rate of 45.1%. |
| Zürcher-Pfund et al. [32] (2013) | 21 | 33% | 0/3 for MRSA. |
| Geurts et al. [13] (2013) | 20 | 85% | Rate of failure associated with number of debridement procedures. |
| Gardner et al. [12] (2011) | 44 | 43% | Staph aureus infection with greater failure. |
| Choi et al. [34] (2011) | 32 | 31% | Staphylococcal infection and polyethylene non-exchange major factors for failure. |
| Koyonos et al. [33] (2011) | 138 | 31% Acute | Staphylococcal infection, most significant indicator of failure. |
| 44% Acute delayed | |||
| 28% Chronic | |||
| Azzam et al. [22] (2010) | 104 | 44% | DAIR has a low success rate. Effective for low virulence organisms. |
| Vilchez et al. [21] (2011) | 65 | Haematogenous PJI – 45% | Haematogenous PJI due to S. aureus, using debridement with implant retention, had a worse outcome than early post-surgical infections. |
| Early PJI – 75% | |||
| Bradbury et al. [26] (2009) | 19 | 18% | The total success rate of open irrigation and debridement with component retention (ODCR) in acute periprosthetic MRSA knee infection was 18%. |
| Chung et al. [45] (2014) | 16 | 100% | 62.5% Arthroscopy alone; the rest needed further open debridement. |
| Liu et al. [43] (2013) | 17 | 88% | Arthroscopic debridement with continuous irrigation and suction effective in prosthesis retention. |
| Mont et al. [44] (1997) | 24 | 80% | DAIR effective for early PJI. |
| Trebse et al. [7] (2005) | 24 | 86% | DAIR effective for treating early PJI. |
| Pavoni et al. [2] (2004) | 34 | 91% | Treatment with long-term antibiotics alone in PJI can yield good results. |
| Sherrell et al. [52] (2011) | 83 | 66% | High failure rate after two-stage revision is worse in patients previously treated with DAIR. |
| Lora-Tamayo et al. [28] (2013) | 345 | 55% | The use of rifampicin may have contributed to homogenizing MSSA and MRSA prognoses, although the specific rifampicin combinations may have had different efficacies. |
| Puhto et al. [49] (2012) | 86 | 89.5% | Shorter course of antibiotics is as effective as longer antibiotics course. |
| Cobo et al. [25] (2011) | 117 | 57.3% | DAIR recommended in early PJI |
| Byren et al. [48] (2009) | 112 | 72% | DAIR effective in PJI |
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