Open Access
Review

Table 1.

Key studies.

Study (year of publication) Number of patients Success rate Comments
Segawa et al. [4] (1999) 81 85% Major factor associated with treatment failure was compromised immune status. Bone loss and necrosis of soft tissues also contributed.
Marculescu et al. [5] (2006) 99 60% Sinus tract and duration of symptoms >8 days independent risk factors for failure.
Hsieh et al. [30] (2009) 346 GN PJI 27% Debridement alone has a high failure rate and should not be attempted when the duration of symptoms is long.
GP PJI 47%
Deirmengian et al. [23] (2003) 31 35% Success rate of DAIR depends on involved pathogen. Streptococcal or Staphylococcus epidermidis has better success rate if done within 2–3 days of symptom onset.
Triantafyllopoulos et al. [29] (2014) 78 55% MRSA success rate of 45.1%.
Zürcher-Pfund et al. [32] (2013) 21 33% 0/3 for MRSA.
Geurts et al. [13] (2013) 20 85% Rate of failure associated with number of debridement procedures.
Gardner et al. [12] (2011) 44 43% Staph aureus infection with greater failure.
Choi et al. [34] (2011) 32 31% Staphylococcal infection and polyethylene non-exchange major factors for failure.
Koyonos et al. [33] (2011) 138 31% Acute Staphylococcal infection, most significant indicator of failure.
44% Acute delayed
28% Chronic
Azzam et al. [22] (2010) 104 44% DAIR has a low success rate. Effective for low virulence organisms.
Vilchez et al. [21] (2011) 65 Haematogenous PJI – 45% Haematogenous PJI due to S. aureus, using debridement with implant retention, had a worse outcome than early post-surgical infections.
Early PJI – 75%
Bradbury et al. [26] (2009) 19 18% The total success rate of open irrigation and debridement with component retention (ODCR) in acute periprosthetic MRSA knee infection was 18%.
Chung et al. [45] (2014) 16 100% 62.5% Arthroscopy alone; the rest needed further open debridement.
Liu et al. [43] (2013) 17 88% Arthroscopic debridement with continuous irrigation and suction effective in prosthesis retention.
Mont et al. [44] (1997) 24 80% DAIR effective for early PJI.
Trebse et al. [7] (2005) 24 86% DAIR effective for treating early PJI.
Pavoni et al. [2] (2004) 34 91% Treatment with long-term antibiotics alone in PJI can yield good results.
Sherrell et al. [52] (2011) 83 66% High failure rate after two-stage revision is worse in patients previously treated with DAIR.
Lora-Tamayo et al. [28] (2013) 345 55% The use of rifampicin may have contributed to homogenizing MSSA and MRSA prognoses, although the specific rifampicin combinations may have had different efficacies.
Puhto et al. [49] (2012) 86 89.5% Shorter course of antibiotics is as effective as longer antibiotics course.
Cobo et al. [25] (2011) 117 57.3% DAIR recommended in early PJI
Byren et al. [48] (2009) 112 72% DAIR effective in PJI

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