Open Access
Issue
SICOT-J
Volume 8, 2022
Article Number 19
Number of page(s) 5
Section Lower Limb
DOI https://doi.org/10.1051/sicotj/2022020
Published online 23 May 2022

© The Authors, published by EDP Sciences, 2022

Licence Creative CommonsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Introduction

Femoral shaft fractures are commonly caused by high-energy trauma. Reduction and internal fixation by the interlocking intramedullary nail is a gold standard [1]. However, nonunion rate after intramedullary nail may reach up to 8% [2].

Factors causing femoral shaft fracture nonunion [2, 3] can be categorized into two main entities; biological factors like soft tissue damage, significant bone injuries, and patient-related factors, i.e., smoking, diabetes, and other comorbidities or biomechanical factors related to fracture location (proximal or distal), nail size, fracture distraction, presence of comminution or implant breakage leading to rotational instability at the fracture site [4, 5].

Treatment of options of femoral shaft nonunions after intramedullary nail includes exchange reamed nailing [6], dynamization of static interlocking nail [7], nail removal, and plate fixation with or without bone graft [8], and nail removal with external fixator application [9]. Plate augmentation with or without bone graft has been described as an effective option for the treatment of femoral fracture nonunion. It improves the biomechanical conditions at the fracture site without adding significant biological damage [1012].

The aim of this study is to assess (1) the rate and time to union following plate augmentation and bone grafting with retention of the nail in case of femoral shaft nonunions with nailing, (2) to identify possible complications of the techniques, and (3) reporting the clinical outcomes.

Materials and methods

Between 2014 and 2021, we retrospectively reviewed all patients who suffered from nonunion femoral shaft fracture after intramedullary interlocking nail fixation at our institution. We included in this study; patients who were treated by plate augmentation and iliac bone graft without nail removal and completed the clinical and radiological schedule of the whole treatment during the follow-up period. Patients with infection, pathological fracture, skeletally immature, patients who were treated by other methods, or patients who did not complete the follow-up schedule were excluded from the study. Approval was obtained from our ethical review board, and informed consent was taken from all patients.

Only 20 of these patients (13 males, 7 females) fulfilled the previous criteria. The average age was 32.4 years (18–55 years). The average time between interlocking nail fixation and plate augmentation was 12 months (8–14 months). The average follow-up after plate augmentation surgery was 13 months (8–15 months).

All cases were closed fractures and were atrophic nonunion. Fifteen cases were treated with closed reduction, while five were treated by open reduction and reamed antegrade interlocking intramedullary nail fixation in the first surgery. Based on the anatomical site of nonunion, 7 cases were isthmic fracture, 3 cases were supraisthmic, and 10 cases were infraisthmic. The mode of trauma and associated injuries are listed in Table 2.

Nonunion was diagnosed by the persistent pain at the fracture site during the stance phase of walking with the absence of progressive callus formation on three monthly follow-up X-rays after 6 months of surgery. Dynamization was previously done for all patients 3–4 months after operation when there were no radiological signs of healing. Laboratory investigations, including Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), were done for all patients to role out infection.

Surgical technique

All patients were operated on under spinal anesthesia in the supine position. Through a lateral approach to the femur, the vastus lateralis muscle was elevated to expose the fracture site. The nonunion site was exposed. Debridement and refreshment of the fracture site were done by removal of all fibrous tissues and making bleeding fracture ends. An autogenous bone graft from the ipsilateral iliac crest was taken and placed at the nonunion site. A conventional broad dynamic compression plate (DCP) was applied to the lateral surface of the femur. Dynamic compression was induced at the nonunion site by axial compression using eccentric placed screws. Although there was slight motion at the fracture site in all cases before plate fixation, this movement completely disappeared after plate fixation. The average operative time was 60 min (range 45–90 min), and the average blood loss was 130 mL (range 100–250 mL). The length of the plate was from 8 to 12 holes. The hospital stay was 24 h in all cases.

Postoperatively, patients were instructed to do knee exercise in the first 2 weeks, and weight-bearing was started with crutches. After 6 weeks, progressive weight-bearing was allowed, followed by full weight-bearing after achieving clinically and radiographical union (Figure 1).

thumbnail Figure 1

Twenty-three year-old lady with atrophic nonunion fracture shaft Rt femur fixed by intramedullary interlocking nail. A. Preoperative X-ray, 9 months after nail fixation, showing; atrophic nonunion at the fracture site. B. Immediate postoperative X-ray after plate and graft augmentation. The fracture was fixed by broad DCP and 8 bicortical screws. The graft can be seen filling the nonunion site. C. 3 months postoperative X-ray showing; complete bone union with good consolidation at fracture site.

Follow-up assessment

Follow-up was carried out every month until there was clinical and radiological evidence of union and every 3 months thereafter until the last follow-up. All patients were evaluated using an X-ray and Wu [13] scoring system, which assesses clinical and radiological signs of healing at the nonunion site (Table 1).

Table 1

Wu criteria for assessment of the healing.

Results

Bony union in X-ray was achieved in all cases (100%). The average time of union was 4.95 months (range 3–8 months). There were no complications recorded.

According to Wu’s score, 12 patients had excellent results, and 8 patients had good results (Table 2).

Table 2

Patients’ data and results.

Discussion

Intramedullary nail has been widely used in femoral shaft fractures, and it has a good reputation regarding union rate [14]. Exchange nailing has been the method of choice for the treatment of nonunion of the femoral shaft following intramedullary nailing [4, 6]. Plate augmentation has been reported to have better results and less complication than exchange nailing [15, 16]. In this series, we used plate augmentation and iliac bone graft without nail removal in all cases. The union rate was 100% achieved after an average time of 4.9 months (3–8 months). We did not report any complications using this technique. We used the Wu score to assess functional results, and we had 12 patients with excellent results and 8 patients with good results.

There are some limitations to this study; the first is retrospective, lack of a control group, and a small number of cases. We reported 20 patients; however, recent studies reported case series included 19–22 patients [1719].

The union rate in our study is comparable to published results (Table 3) of other studies using plate augmentation with bone graft. In a retrospective study of 40 patients presented with nonunion of the femoral shaft after treatment with an interlocking intramedullary nail, Jhunjhunwala and Dhawale reported a union rate of 97.5% using plate augmentation [12]. In their study, adding autogenous iliac bone graft was done in 24 patients with oligotrophic nonunion. Nail exchange with larger size nails was done in nine patients. However, they did not describe how they selected patients for each procedure.

Table 3

Review of literature of relevant studies about plate augmentation.

In another series by Chiang et al., 30 patients were treated with plate augmentation without nail removal, bone union occurred in 29 patients [10]. Biologic supplementation was done with autogenous iliac bone graft and bone morphogenetic protein for selected patients with Atrophic nonunion. However, the indication of why and when this was needed was not clear. In their series, there were seven patients with atrophic nonunion, 18 patients with oligotrophic nonunion, and five patients with hypertrophic nonunion.

The same results were obtained by Vaishya et al. in their retrospective study of 16 patients with femoral shaft nonunion after interlocking nail fixation [20]. Autologous cortico-cancellous bone graft was done only in patients with atrophic nonunion, and they did not apply interfragmentary compression at the site of nonunion to achieve bone healing.

We did not encounter any complications in our series, which is similar to other recent studies [1719]. While few studies reported non-serious wound infection in one patient, each of which was treated successfully [10, 12, 20]. These reports support the safety of this technique.

Only a few studies used clinical scores to assess results [1719], while other studies depended only on radiological healing [10, 20, 21]. We used the Wu score to assess results, and we had 12 excellent and 8 good results. Only one recently published study by Uliana et al. [17] used the same score and showed comparable results to our study.

Exchange nailing has been the method of choice for the treatment of nonunion of the femoral shaft [15, 16]. Exchange nailing can be challenging, sometimes due to the presence of broken locking screws, broken nails, and heterotopic calcification at the entry. Technical problems related to the implant used and surgical techniques, which are often unknown when the patient was referred from another hospital, are not uncommon [15, 16]. Failure of exchange nailing has been reported in long bone nonunions accompanied by fracture comminution, bone defects, and metaphyseal-diaphyseal junctional fractures. Also, exchanging the nail with a larger size nail is not applicable if the nail already used is the largest diameter as produced by the manufacturer [16].

In our study, 20 (100%) patients had a large fragment DCP with bicortical screw fixation. In addition, axial compression at the nonunion site was achieved by eccentric screw position within the plate. Most authors used large set plates (non-locked or locked) with bicortical screws whenever possible [11, 20, 21]. In a recent systematic review, Medlock et al. [15] reported that when using a compression mode, large set plates and screws construction helps prevent excessive axial displacement when dynamization was only done. In addition, plate augmentation leaving the nail in situ construction is stiff enough to overcome the rotational instability commonly seen at the nonunion site, adding more mechanical stability for bone healing and early weight-bearing [22].

Iliac bone graft is the key to success in plate augmentation technique [10, 11]. The value of biological supplementation by iliac bone graft has been highlighted by previous authors, who did it for all cases of atrophic nonunion and the majority of hypertrophic nonunion cases [10, 11]. Most authors recommended using autogenous iliac cortico-cancellous bone grafts regardless of the size of the defect [10, 12].

In conclusion, plate augmentation with iliac bone graft is an effective and safe treatment of nonunion femoral shaft fracture in patients previously treated by interlocking nails. It provides a high union rate and good clinical results.

Conflict of interest

The authors declare that they have no relevant financial or non-financial interests to report.

Funding

This research did not receive any specific funding.

Ethical approval

This study received ethical approval from the Ethics committee of Faculty of Medicine, Sohag University, Sohag, Egypt.

Informed consent

Written informed consent was obtained from all patients.

Authors contributions

M. Mohamed: Writing original draft, Investigation; H. Noaman: Visualization, Supervision; Y. Soroor: Conceptualization, Methodology; M. Elsayed: Writing, Reviewing and Editing.

References

  1. Winquist RA, Hansen ST, Clawson DK (1984) Closed intramedullary nailing of femoral fractures. A report of five hundred and twenty cases. J Bone Joint Surg Am 66(4), 529–539. [CrossRef] [PubMed] [Google Scholar]
  2. Rupp M, Biehl C, Budak M, Thormann U, Heiss C, Alt V (2018) Diaphyseal long bone nonunions – types, aetiology, economics, and treatment recommendations. Int Orthop 42(2), 247–258. [CrossRef] [PubMed] [Google Scholar]
  3. Park J, Kim SG, Yoon HK, Yang KH (2010) The treatment of nonisthmal femoral shaft nonunions with IM nail exchange versus augmentation plating. J Orthop Trauma 24(2), 89–94. [CrossRef] [PubMed] [Google Scholar]
  4. Brinker MR, O’Conor DP (2007) Exchange nailing of ununited fractures. J Bone Joint Surg Am 89(1), 177–188. [CrossRef] [PubMed] [Google Scholar]
  5. Nadkarni B, Srivastav S, Mittal V, Agarwal S (2008) Use of locking compression plates for long bone nonunions without removing existing intramedullary nail: review of literature and our experience. J Trauma 65(2), 482–486. [PubMed] [Google Scholar]
  6. Hak DJ, Lee SS, Goulet JA (2000) Success of exchange reamed intramedullary nailing for femoral shaft nonunion or delayed union. J Orthop Trauma 14(3), 178–182. [CrossRef] [PubMed] [Google Scholar]
  7. Litrenta J, Tornetta P 3rd, Vallier H et al. (2015) Dynamizations and exchanges: success rates and indications. J Orthop Trauma 29(12), 569–573. [CrossRef] [PubMed] [Google Scholar]
  8. Gardner MJ, Toro-Arbelaez JB, Harrison M, Hierholzer C, Lorich DG, Helfet DL (2008) Open reduction and internal fixation of distal femoral nonunions: long-term functional outcomes following a treatment protocol. J Trauma 64(2), 434–438. [PubMed] [Google Scholar]
  9. Menon DK, Dougall TW, Pool RD, Simonis RB (2002) Augmentative Ilizarov external fixation after failure of diaphyseal union with intramedullary nailing. J Orthop Trauma 16(7), 491–497. [CrossRef] [PubMed] [Google Scholar]
  10. Chiang JC, Johnson JE, Tarkin IS, Siska PA, Farrell DJ, Mormino MA (2016) Plate augmentation for femoral nonunion: more than just a salvage tool? Arch Orthop Trauma Surg 136(2), 149–156. [CrossRef] [PubMed] [Google Scholar]
  11. Garnavos C (2017) Treatment of aseptic non-union after intramedullary nailing without removal of the nail. Injury 48(Suppl 1), S76–S81. [CrossRef] [PubMed] [Google Scholar]
  12. Jhunjhunwala HR, Dhawale AA (2016) Is augmentation plating an effective treatment for non-union of femoral shaft fractures with nail in situ? Eur J Trauma Emerg Surg 42(3), 339–343. [CrossRef] [PubMed] [Google Scholar]
  13. Wu CC (2001) Treatment of femoral shaft aseptic nonunion associated with plating failure: emphasis on the situation of screw breakage. J Trauma 51(4), 710–713. [CrossRef] [PubMed] [Google Scholar]
  14. Wu CC, Shih CH (1992) Treatment of 84 cases of femoral nonunion. Acta Orthop Scand 63(10), 57–60. [PubMed] [Google Scholar]
  15. Medlock G, Stevenson IM, Johnstone AJ (2018) Uniting the un-united: should established non-unions of femoral shaft fractures initially treated with IM nails be treated by plate augmentation instead of exchange IM nailing? A systematic review. Strateg Trauma Limb Reconstr 13(3), 119–128. [Google Scholar]
  16. Weresh MJ, Hakanson R, Stover M, Sims SH, Kellam JF, Bosse MJ (2000) Failure of exchange reamed intramedullary nails for ununited femoral shaft fractures. J Orthop Trauma 14(5), 335–338. [CrossRef] [PubMed] [Google Scholar]
  17. Uliana CS, Bidolegui F, Kojima K, Giordano V (2021) Augmentation plating leaving the nail in situ is an excellent optionfor treating femoral shaft nonunion after IM nailing: a multicenter study. Eur J Trauma Emerg Surg 47, 1895–1901. [CrossRef] [PubMed] [Google Scholar]
  18. Ebrahimpour A, Chehrassan M, Biglari F, Sajjadi MM, Jalalpour P, Sadighi M (2021) Augmented Plating and Bone Grafting in Treatment of Tibial and Femoral Shaft Nonunion. Trauma Mon 26(4), 187–193. [Google Scholar]
  19. Mittal KK, Gupta H, Kaushik N (2021) Reunion of post nail aseptic non-union of diaphyseal femoral fractures by augmentation plating, decortication and bone grafting –Replacement for exchange nailing. Injury 52(6), 1529–1533. [CrossRef] [PubMed] [Google Scholar]
  20. Vaishya R, Agarwal AK, Gupta N, Vijay V (2016) Plate augmentation with retention of intramedullary nail is effective for resistant femoral shaft non-union. J Orthop 13(4), 242–245. [CrossRef] [PubMed] [Google Scholar]
  21. Birjandinejad A, Ebrahimzadeh MH, Ahmadzadeh-Chabock H (2009) Augmentation plate fixation for the treatment of femoral and tibial nonunion after intramedullary nailing. Orthopedics 32(6), 409. [PubMed] [Google Scholar]
  22. Park K, Kim K, Choi YS (2011) Comparison of mechanical rigidity between plate augmentation leaving the nail in situ and interlocking nail using cadaveric fracture model of the femur. Int Orthop 35, 581–585. [CrossRef] [PubMed] [Google Scholar]

Cite this article as: Mohamed MA, Noaman HH, Soroor YO & Elsayed M (2022) Plate augmentation and bone grafting in treatment of femoral shaft nonunion initially fixed by intramedullary nail. SICOT-J 8, 19

All Tables

Table 1

Wu criteria for assessment of the healing.

Table 2

Patients’ data and results.

Table 3

Review of literature of relevant studies about plate augmentation.

All Figures

thumbnail Figure 1

Twenty-three year-old lady with atrophic nonunion fracture shaft Rt femur fixed by intramedullary interlocking nail. A. Preoperative X-ray, 9 months after nail fixation, showing; atrophic nonunion at the fracture site. B. Immediate postoperative X-ray after plate and graft augmentation. The fracture was fixed by broad DCP and 8 bicortical screws. The graft can be seen filling the nonunion site. C. 3 months postoperative X-ray showing; complete bone union with good consolidation at fracture site.

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