Risk factors for peri-megaprosthetic joint infections in tumor surgery: A systematic review

Special issue: "Bone and joint infections"

Open Access

Review

Table 2

Summary of published studies reporting on antibiotics regimens for perioperative prophylaxis.

Study	Antibiotics regimen	Duration of antibiotics administration
Khakzad et al. [10]	– Ampicillin/sulbactam (usually 3 × 3 g i.v.)	–
Streitbuerger et al. [13]	i.v. 3rd-generation cephalosporin Oral therapy with a second-generation cephalosporin	Postoperatively: i.v. antibiotics for 3–7 days Oral antibiotics until wound healing is achieved
Jeys et al. [2]	i.v. dose of a broad-spectrum cephalosporin	Pre-operatively
Gosheger et al. [23]	i.v. cephalosporin	Postoperatively: i.v. antibiotics for 3–7 days Oral antibiotics until wound healing is achieved
Hardes et al. [16]	i.v. 3rd-generation cephalosporin Oral therapy with a second-generation cephalosporin	Postoperatively: i.v. for 3–7 days Oral therapy until wound healing was achieved
Peel et al. [20]	i.v. vancomycin was included in the surgical antibiotic prophylaxis regimen in 55 patients 87 patients had ongoing oral prophylactic antibiotics with cephalexin	Postoperatively: Median duration of i.v. antibiotics prophylaxis was 4 days Median ongoing oral antibiotics administration was 6 days Total post-operative antibiotics prophylaxis was 11 days
Morii et al. [22]	–	Post-operatively: Antibiotics were given for >72 h
Dhanoa et al. [17]	i.v. cefuroxime 30 min before incision and post-operatively. i.v. vancomycin for allergic patients	Post-operatively: For 5 days
Mavrogenis et al. [18]	Adults: Cefuroxime 750 mg/8 h (1983–1987) Teicoplanin 400–600 mg/day (1987–2010) Amikacin 500 mg/12 h (2 doses) (1983–2010)	Post-operatively: Cefuroxime for 5 days Teicoplanin for 1 day Amikacin; 2 doses Ceftriaxone in children for 5 days
	Children (<30 kg body weight): Ceftriaxone 30 mg/day (1983–2010)

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