Volume 3, 2017
|Number of page(s)||8|
|Published online||06 March 2017|
A systematic review of the concept and clinical applications of Bone Marrow Aspirate Concentrate in Orthopaedics
Department of Trauma and Orthopaedics, Faculty of Medicine, Suez Canal University, 41111
2 The Royal Orthopaedic Hospital, B31 2AP Birmingham, UK
3 Health Education North East of England, NE15 8NY Newcastle, UK
4 Birmingham University, B15 2TT Birmingham, UK
5 Research and Development, OxCell, OX3 8AT Oxford, UK
6 Institute of Biomedical Engineering, University of Oxford, OX3 7DQ Oxford, UK
* Corresponding author: firstname.lastname@example.org
Accepted: 8 January 2017
Introduction: Mesenchymal stem cells (MSC’s) are believed to have multipotent plasticity with the capability to differentiate along multiple cell lineages such as cartilage, bone, tendon, muscle, and nerve. Such multipotency has the potential to play an important role in the repair and reconstruction of multiple tissues across a number of orthopaedic specialties. Bone marrow and fat are the most abundant and accessible source of MSC’s with bone marrow aspirate the most commonly being reported to stimulate healing.
Methods: This review examines the current reported 20 Q2 clinical applications of bone marrow aspirate concentrate and its effectiveness.
Results: The published studies reported techniques of collection and preparation of BMAC in addition to its applications in a number of orthopaedic sub-specialities. Studies could be sub-categorised into: techniques of extraction, processing and microscopic examination of BMAC (31), reconstruction of osseous defects/non-union (20), treatment of avascular necrosis (9), repair of cartilage defects (8), treatment of sports injuries and tendon injury/repair (9), injection in regenerative therapy (4), treatment of spine conditions (4) including enhancing postoperative fusion and degenerative disc pathology and orthopaedic oncology (4). A few published studies combined the use of platelet-rich plasma (PRP) with BMAC (4) or compared them in different applications (5).
Conclusions: BMAC has been used in bone, cartilage and tendon injuries with encouraging results.
Key words: Bone Marrow Aspirate Concentrate / BMAC / Mesenchymal Stem Cells
© The Authors, published by EDP Sciences, 2017
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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